From the NIOSH Science Blog:

The toxic nature of 1-BP is not fully understood. Case reports demonstrating neurotoxic, reproductive, development and other health effects in workers who use or make 1-BP indicate that the brominated solvent may represent an unrecognized occupational health risk:

Neurologic Illness Associated with Occupational Exposure to the Solvent 1-Bromopropane — New Jersey and Pennsylvania, 2007–2008

In recent years we have seen an increase in the use of the solvent 1-bromopropane (1-BP) as a substitute for ozone-depleting chlorofluorocarbons and other regulated compounds. 1-BP is used in multiple manufacturing processes, including vapor and immersion degreasing operations to clean electronics and metal and as a solvent vehicle in industries using aerosol applied adhesives such as foam cushion manufacturing.

Limited exposure and human health effect data are currently available concerning 1-BP, but the National Toxicology Program (NTP) has concluded that there is sufficient evidence of developmental and reproductive toxicity among animals exposed to 1-BP. NIOSH is in the process of evaluating exposures and potential health effects among workers potentially exposed to 1-BP.

Currently, NIOSH does not have a Recommended Exposure Limit (REL), nor does the Occupational Safety and Health Administration (OSHA) have a Permissible Exposure Limit (PEL) for 1-BP.

The American Conference of Governmental Industrial Hygienists (ACGIH) recommends an 8-hour time weighted average (TLV) of 10 parts per million (ppm) to provide protection against the potential for neurotoxicity, hepatotoxicity, and reproductive and developmental toxicity in 1-BP exposed workers.  The U.S. Environmental Protection Agency stated in May 2007 that exposures within or below the range of 17 to 30 ppm are anticipated to be protective against reproductive effects in men and women.

NIOSH initially investigated the hazards of occupational exposure to 1-BP within a series of Health Hazard Evaluations (HHEs). The HHEs assessed the use of 1-BP within vapor degreasing operations in an electronics cleaning facility and as a solvent vehicle within the application of spray adhesives during foam cushion manufacturing. Links to the results of these studies can be found on the NIOSH Science Blog.