Open access article: Melanoma: What Are the Gaps in Our Knowledge by Jonathan Rees PLoS Medicine
A short introduction:
Cutaneous malignant melanoma (MM) falls into two main groups, based on aetiology. First, a small minority of patients have acral MM, in which the disease occurs on the palms and soles. Acral melanomas are therefore not believed to be causally related to UVR, and their aetiology remains a mystery. They will not be discussed further in this article. By contrast, more than 90% of MM occurs on non-acral sites and is thought to be caused by UVR [2,4].
The evidence for such causality comes from a variety of fields. MM is most common in those with pale skin, which has a relative lack of melanin, a substance that blocks photons from penetrating deeply into skin. African people with very dark skin are hundreds of times less sensitive to the harmful effects of UVR than white Northern Europeans.
Even within white Northern European populations, MM rates vary in relation to more subtle degrees of difference in sun sensitivity. Those with red hair, pale skin, and a tendency to freckle are about three times more likely to develop MM than those without these three features. The dramatically elevated rate of MM in those with European ancestry in Australia is therefore what we would expect: susceptibility of the host coupled with enhanced environmental exposure leads to a high disease risk.
Given that we know the major host and environmental factors that lead to non-acral malignant melanomas, one might think that we know enough to reduce the incidence of MM.
But our ability to change people’s behaviour so that they reduce their exposure to UVR remains limited. In addition, as our knowledge of MM has increased, so has the incidence of disease. Puzzling gaps therefore remain in our knowledge of the aetiology of non-acral melanomas. So what important things do we not know?
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Open access article: Melanoma: What Are the Gaps in Our Knowledge by Jonathan Rees PLoS Medicine
Filed under: Occupational cancer, Occupational exposure, Skin, UV