Ramazzini; Blog on work and health by Annet Lenderink

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Case report on allergic reaction to rhodium salts

Whereas platinum salts are well known occupational allergens, rhodium salts have not been identified as inhalative sensitizing substances. A 27-year-old atopic operator of an electroplating plant developed work-related shortness of breath and runny nose with sneezing after exposure to rhodium salts. The patient showed positive skin prick test reactions and positive bronchial immediate-type reactions with rhodium and platinum salts. Sensitivity to rhodium salt was much higher than to platinum salt. Rhodium salts should be considered as occupational immediate-type allergens.

Occupational immediate-type asthma and rhinitis due to rhodium salts
Rolf Merget, MD, Ingrid Sander, PhD, Vera van Kampen, PhD , Monika Raulf-Heimsoth, PhD , Hans-Martin Ulmer, MD, Rupprecht Kulzer, MD , Thomas Bruening, MD  Am. J. Ind. Med. 2009, Accepted: 9 October 2009

Abstract

Background: Whereas platinum salts are well known occupational allergens, rhodium salts have not been identified as inhalative sensitizing substances.

Methods: A 27-year-old atopic operator of an electroplating plant developed work-related shortness of breath and runny nose with sneezing after exposure to rhodium salts. Quantitative skin prick tests (SPT) and bronchial challenge tests with a dosimeter protocol were performed with quadrupling doses of the sodium chloride salts of rhodium (Na3RhCl6) and platinum (Na2PtCl6).

Results: The patient showed positive SPT reactions and positive bronchial immediate-type reactions with rhodium and platinum salts. Sensitivity to rhodium salt was much higher than to platinum salt; the molar concentrations differed by a factor of 256 in SPT and a factor of 16 in bronchial challenges.

Conclusions: Rhodium salts should be considered as occupational immediate-type allergens.

Filed under: Allergies, Chemical agents, lung, Nose, ,

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