Ramazzini; Blog on work and health by Annet Lenderink


Case report on allergic reaction to rhodium salts

Whereas platinum salts are well known occupational allergens, rhodium salts have not been identified as inhalative sensitizing substances. A 27-year-old atopic operator of an electroplating plant developed work-related shortness of breath and runny nose with sneezing after exposure to rhodium salts. The patient showed positive skin prick test reactions and positive bronchial immediate-type reactions with rhodium and platinum salts. Sensitivity to rhodium salt was much higher than to platinum salt. Rhodium salts should be considered as occupational immediate-type allergens.

Occupational immediate-type asthma and rhinitis due to rhodium salts
Rolf Merget, MD, Ingrid Sander, PhD, Vera van Kampen, PhD , Monika Raulf-Heimsoth, PhD , Hans-Martin Ulmer, MD, Rupprecht Kulzer, MD , Thomas Bruening, MD  Am. J. Ind. Med. 2009, Accepted: 9 October 2009 Read the rest of this entry »

Filed under: Allergies, Chemical agents, lung, Nose, ,

Long latency and banal symptoms in sinonasal adenocarcinoma

Sinonasal adenocarcinoma is a rare cancer, frequently associated with occupational exposure to inhalable wood dust. This case–control study was aimed at assessing potential risk factors and at characterizing initial clinical symptoms, both serving as matrix to identify persons at increased risk and to improve management of this cancer.

Cases were significantly engaged in mainly woodworking occupations compared to controls. The main initial clinical symptoms were nasal obstruction 6 months (71%) and epistaxis 4 years (41.9%) prior to diagnosis. Hardwood dust from beech and oak proved to be the most common occupational exposure, with a mean exposure period of 32.3 years and a latency of 43.5 (34–58) years.

The researchers conclude  that the study confirms the importance of regular screenings for persons exposed to wood dust even years after the end of occupational or private exposure. Banal clinical symptoms such as epistaxis and nasal obstruction might be predictive, requiring early and thorough investigation.

Characterization of initial clinical symptoms and risk factors for sinonasal adenocarcinomas: results of a case–control study
by Susanne Mayr, Kamber Hafizovic, Frank Waldfahrer, Heinrich Iro, Birgitta Kütting International Archives of Occupational and Environmental Health Read the rest of this entry »

Filed under: Chemical agents, Nose, Occupational cancer, ,

Rhinitis related to application of some pesticides

rhinitisTo investigate the association between current rhinitis and pesticide use, a study was performed using data from 2245 Iowa commercial pesticide applicators in the Agricultural Health Study. Five pesticides used in the past year were significantly positively associated with current rhinitis: the herbicides 2,4-D, glyphosate and petroleum oil, the insecticide diazinon and the fungicide benomyl.

Rhinitis associated with pesticide exposure among commercial pesticide applicators in the Agricultural Health Study
R E Slager, J A Poole, T D LeVan, D P Sandler, M C R Alavanja, J A Hoppin
Occupational and Environmental Medicine 2009;66:718-724 Read the rest of this entry »

Filed under: Chemical agents, Nose, Occupational exposure, ,


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Annet Lenderink

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