Ramazzini; Blog on work and health by Annet Lenderink

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Exploring new models for occupational cancer surveillance in Canada

Presentation 28-11-2012 53 min. 22 sec

Dr. Paul Demers is the director of the Occupational Cancer Research Centre in Toronto, based at Cancer Care Ontario. He is also the scientific director of CAREX Canada, a national workplace and environmental carcinogen surveillance program, as well as a professor with the Dalla Lana School of Public Health at the University of Toronto and a clinical professor with the School of Population and Public Health at the University of British Columbia. He is an epidemiologist whose research focuses on occupational cancer and other chronic diseases.

Filed under: Occupational cancer, ,

Suggestive relation between multiple myeloma and chlorinated solvent exposure

The relationship between multiple myeloma and occupational exposure to six chlorinated solvents
Laura S Gold et al. 2011

Evidence from a relatively large case-control study (181 cases (71% response) vs. 481 controls (52% response)) suggests that exposures to certain chlorinated solvents may be associated with increased incidence of multiple myeloma; however, the study is limited by relatively low participation (52%) among controls

What this paper adds:

  • The aetiology of multiple myeloma is poorly understood.

  • The purpose of this research was to examine relationships between occupational exposures to chlorinated solvents and multiple myeloma.
  • This research provides evidence that certain chlorinated solvents, most notably trichloroethylene, are associated with increased incidence of multiple myeloma.

  • While results were less clear, exposure to 1,1,1-trichloroethane, methylene chloride, perchloroethylene, carbon tetrachloride and chloroform also conferred increased risk of multiple myeloma in our population. Read the rest of this entry »

Filed under: Chemical agents, Occupational cancer, ,

How to influence health behaviour to prevent skin cancer?

Skin cancer is an increasing problem in Europe, America and Australasia, although largely preventable by avoiding excessive ultraviolet (UV) exposure. The aim of this study was to understand elements that may contribute to the successful or unsuccessful conveyance of skin cancer prevention messages and their uptake by the public. This showed that most people perceived their susceptibility to skin cancer, and its severity, as low. While benefits of adopting changed behaviour were acknowledged, there were substantial barriers to this, including positive perceptions of a tan as healthy and attractive and the hassle of covering up or using sunscreen.

What influences the uptake of information to prevent skin cancer? A systematic review and synthesis of qualitative research
Ruth Garside, Mark Pearson and Tiffany Moxham Health Education Research 2010 25(1):162-182

Read the rest of this entry »

Filed under: No category, Occupational cancer, Skin, , ,

Pleural mesothelioma in Mexican workers often related to work

Mexican study: To identify the proportion of cases of malignant pleural mesothelioma (MPM) that can be attributed to and occupational exposure to asbestos, we carried out a case-control study in 472 workers: 119 incident cases and 353 controls. Odds Ratios, adjusted for age and gender and by exposure category, exhibited an increase with probability of exposure as follows: 3.7(95% CI 1.3-10.4) for the likely category and 14.3(95% CI 8-26) for the certain category; Attributable risks (AR) in the group occupationally exposed to asbestos was 83.2%, and the population AR was 44%. The results show that the relationship between industrial uses of all forms of asbestos is generating an increase in mesothelioma-related diseases and deaths among Mexican workers

Case-control study of pleural mesothelioma in workers with social security in Mexico
Guadalupe Aguilar-Madrid, MD, MSc, PhD, Eduardo Robles-Pérez, MD, MSc, Cuauhtémoc Arturo Juárez-Pérez, MD, MSc, Isabel Alvarado-Cabrero, MD, Flavio Gerardo Rico-Méndez, MD, Kelly-García Javier, MD 
American Journal of Industrial Medicine, published online 16 Dec 2009 Read the rest of this entry »

Filed under: Chemical agents, Mesothelioma, Occupational cancer, Occupational exposure, ,

Long latency and banal symptoms in sinonasal adenocarcinoma

Sinonasal adenocarcinoma is a rare cancer, frequently associated with occupational exposure to inhalable wood dust. This case–control study was aimed at assessing potential risk factors and at characterizing initial clinical symptoms, both serving as matrix to identify persons at increased risk and to improve management of this cancer.

Cases were significantly engaged in mainly woodworking occupations compared to controls. The main initial clinical symptoms were nasal obstruction 6 months (71%) and epistaxis 4 years (41.9%) prior to diagnosis. Hardwood dust from beech and oak proved to be the most common occupational exposure, with a mean exposure period of 32.3 years and a latency of 43.5 (34–58) years.

The researchers conclude  that the study confirms the importance of regular screenings for persons exposed to wood dust even years after the end of occupational or private exposure. Banal clinical symptoms such as epistaxis and nasal obstruction might be predictive, requiring early and thorough investigation.

Characterization of initial clinical symptoms and risk factors for sinonasal adenocarcinomas: results of a case–control study
by Susanne Mayr, Kamber Hafizovic, Frank Waldfahrer, Heinrich Iro, Birgitta Kütting International Archives of Occupational and Environmental Health Read the rest of this entry »

Filed under: Chemical agents, Nose, Occupational cancer, ,

Insurance and claim data on occupational diseases

Last year, the number of occupational disease claims rose by 6% according to figures from the Center for Insurance Statistics (CVS) in the Netherlands. More than three quarters of these claims relate to asbestos-related diseases. The reports of mesothelioma increased by 10% and its financial burden increased by 72% to 10 million euros.

The annual financial burden of all occupational diseases is 14 million euros. This burden increased by 46% in 2008 as compared to 2007 . Nellie Martens, linked to the Asbestos Institute, explains the long latency of asbestos: it takes on average 38 years before mesothelioma becomes visible. Since only in 1993 the asbestos ban went into force, it is to be expected that more patients will be diagnosed in the coming years. Until 2017 the number of victims will remain stable or rise slightly, and after that the number decreased gradually.

The average claim size of occupational diseases has increased slightly over 2008 and came out to almost 31,000 euros. Mesothelioma claims increased the most, rising almost 20%. The RSI claims have fallen sharply in the past six years.

Filed under: Mesothelioma, Workers' compensation, , , , ,

HSE Podcast “Asbestos: The Hidden Killer”

In the October podcast, HSE’s Steve Coldrick talks about the Asbestos – the Hidden Killer campaign:

Listen to October 2009 Podcast – Asbestos: The Hidden Killer

 

Filed under: Chemical agents, Mesothelioma, Occupational cancer,

Asbestosis figures from British Columbia

To get insight in the true burden of asbestosis in the population it’s not enough to rely on a single source. Triangulation of workers’ compensation, hospitalisation and outpatient databases records is necessary to get a better picture.

Population-based asbestosis surveillance in British Columbia
W Q Gan, P A Demers, C B McLeod M Koehoorn
Occupational and Environmental Medicine 2009;66:766-771  Read the rest of this entry »

Filed under: Chemical agents, lung, Mesothelioma, ,

Paternal occupational exposure and retinoblastoma?

To examine the association between paternal occupational exposures and retinoblastoma using birth registration data a case–control study was carried out.  For 1318 cases of retinoblastoma, born and diagnosed in Great Britain between 1962 and 1999, and 1318 controls matched on sex, date of birth and birth registration sub-district paternal occupations at birth were grouped according to inferred exposure using an occupational exposure classification scheme.

For non-heritable retinoblastoma, a statistically significant increased risk was found with father’s definite occupational exposure to oil mists in metal working (OR = 1.85 (95% CI 1.05 to 3.36)). No statistically significant associations were observed for other exposure groups.

Overall, our findings do not support the hypothesis that paternal occupational exposure is an important aetiological factor for retinoblastoma, however, the study has low power and other methodological limitations.

Paternal occupation and retinoblastoma: a case–control study based on data for Great Britain 1962–1999
A MacCarthy, K J Bunch1, N T Fear2, J C King, T J Vincent1, M F G Murphy Occupational and Environmental Medicine 2009;66:644-649  Read the rest of this entry »

Filed under: Chemical agents, Occupational cancer, ,

Frequent degreasing may be associated to non-Hodgkin lymphoma

To investigate the relationship between selected solvent-related workplace tasks (degreasing, painting, gluing, stripping paint, staining) and risk of non-Hodgkin lymphoma (NHL) occupational data from a large population-based case-control study of NHL conducted in the USA were analysed.

We observed an increased risk of NHL among subjects in the highest category of maximal degreasing frequency (>520 h/year: OR 2.1, 95% CI 0.9 to 4.9, trend test p = 0.02). We found similar associations for the highest levels of average frequency and, among men, cumulative number of hours. Other solvent-related tasks were not associated with NHL. Frequent degreasing work may be associated with an elevated risk of NHL

[Short report] Degreasing and risk of non-Hodgkin lymphoma by Purdue, M P, Severson, R K, Colt, J S, Stewart, P, De Roos, A J, Cerhan, J R, Cozen, W, Davis, S, Hartge, P, Schenk, M, Blair, A Occupational and Environmental Medicine 2009;66:557-560

Read the rest of this entry »

Filed under: Chemical agents, Occupational cancer, Occupational exposure, ,

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Annet Lenderink

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