Ramazzini; Blog on work and health by Annet Lenderink

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Exploring new models for occupational cancer surveillance in Canada

Presentation 28-11-2012 53 min. 22 sec

Dr. Paul Demers is the director of the Occupational Cancer Research Centre in Toronto, based at Cancer Care Ontario. He is also the scientific director of CAREX Canada, a national workplace and environmental carcinogen surveillance program, as well as a professor with the Dalla Lana School of Public Health at the University of Toronto and a clinical professor with the School of Population and Public Health at the University of British Columbia. He is an epidemiologist whose research focuses on occupational cancer and other chronic diseases.

Filed under: Occupational cancer, ,

Pleural mesothelioma in Mexican workers often related to work

Mexican study: To identify the proportion of cases of malignant pleural mesothelioma (MPM) that can be attributed to and occupational exposure to asbestos, we carried out a case-control study in 472 workers: 119 incident cases and 353 controls. Odds Ratios, adjusted for age and gender and by exposure category, exhibited an increase with probability of exposure as follows: 3.7(95% CI 1.3-10.4) for the likely category and 14.3(95% CI 8-26) for the certain category; Attributable risks (AR) in the group occupationally exposed to asbestos was 83.2%, and the population AR was 44%. The results show that the relationship between industrial uses of all forms of asbestos is generating an increase in mesothelioma-related diseases and deaths among Mexican workers

Case-control study of pleural mesothelioma in workers with social security in Mexico
Guadalupe Aguilar-Madrid, MD, MSc, PhD, Eduardo Robles-Pérez, MD, MSc, Cuauhtémoc Arturo Juárez-Pérez, MD, MSc, Isabel Alvarado-Cabrero, MD, Flavio Gerardo Rico-Méndez, MD, Kelly-García Javier, MD 
American Journal of Industrial Medicine, published online 16 Dec 2009 Read the rest of this entry »

Filed under: Chemical agents, Mesothelioma, Occupational cancer, Occupational exposure, ,

Long latency and banal symptoms in sinonasal adenocarcinoma

Sinonasal adenocarcinoma is a rare cancer, frequently associated with occupational exposure to inhalable wood dust. This case–control study was aimed at assessing potential risk factors and at characterizing initial clinical symptoms, both serving as matrix to identify persons at increased risk and to improve management of this cancer.

Cases were significantly engaged in mainly woodworking occupations compared to controls. The main initial clinical symptoms were nasal obstruction 6 months (71%) and epistaxis 4 years (41.9%) prior to diagnosis. Hardwood dust from beech and oak proved to be the most common occupational exposure, with a mean exposure period of 32.3 years and a latency of 43.5 (34–58) years.

The researchers conclude  that the study confirms the importance of regular screenings for persons exposed to wood dust even years after the end of occupational or private exposure. Banal clinical symptoms such as epistaxis and nasal obstruction might be predictive, requiring early and thorough investigation.

Characterization of initial clinical symptoms and risk factors for sinonasal adenocarcinomas: results of a case–control study
by Susanne Mayr, Kamber Hafizovic, Frank Waldfahrer, Heinrich Iro, Birgitta Kütting International Archives of Occupational and Environmental Health Read the rest of this entry »

Filed under: Chemical agents, Nose, Occupational cancer, ,

Paternal occupational exposure and retinoblastoma?

To examine the association between paternal occupational exposures and retinoblastoma using birth registration data a case–control study was carried out.  For 1318 cases of retinoblastoma, born and diagnosed in Great Britain between 1962 and 1999, and 1318 controls matched on sex, date of birth and birth registration sub-district paternal occupations at birth were grouped according to inferred exposure using an occupational exposure classification scheme.

For non-heritable retinoblastoma, a statistically significant increased risk was found with father’s definite occupational exposure to oil mists in metal working (OR = 1.85 (95% CI 1.05 to 3.36)). No statistically significant associations were observed for other exposure groups.

Overall, our findings do not support the hypothesis that paternal occupational exposure is an important aetiological factor for retinoblastoma, however, the study has low power and other methodological limitations.

Paternal occupation and retinoblastoma: a case–control study based on data for Great Britain 1962–1999
A MacCarthy, K J Bunch1, N T Fear2, J C King, T J Vincent1, M F G Murphy Occupational and Environmental Medicine 2009;66:644-649  Read the rest of this entry »

Filed under: Chemical agents, Occupational cancer, ,

Frequent degreasing may be associated to non-Hodgkin lymphoma

To investigate the relationship between selected solvent-related workplace tasks (degreasing, painting, gluing, stripping paint, staining) and risk of non-Hodgkin lymphoma (NHL) occupational data from a large population-based case-control study of NHL conducted in the USA were analysed.

We observed an increased risk of NHL among subjects in the highest category of maximal degreasing frequency (>520 h/year: OR 2.1, 95% CI 0.9 to 4.9, trend test p = 0.02). We found similar associations for the highest levels of average frequency and, among men, cumulative number of hours. Other solvent-related tasks were not associated with NHL. Frequent degreasing work may be associated with an elevated risk of NHL

[Short report] Degreasing and risk of non-Hodgkin lymphoma by Purdue, M P, Severson, R K, Colt, J S, Stewart, P, De Roos, A J, Cerhan, J R, Cozen, W, Davis, S, Hartge, P, Schenk, M, Blair, A Occupational and Environmental Medicine 2009;66:557-560

Read the rest of this entry »

Filed under: Chemical agents, Occupational cancer, Occupational exposure, ,

More lungcancer in female pulp and paper mill workers

To study cancer mortality among Swedish pulp and paper mill workers by main mill pulping process and department a cohort of 18,163 male and 2,290 female workers at four sulfate and four sulfite mills, enrolled from 1939 to 1999, was followed up for mortality during 1952–2001.

Standardized mortality ratios (SMRs) relative to the general Swedish population were calculated. Total cancer mortality was not increased in either sulfate or sulfite mill workers, or by gender. Lung cancer mortality was increased among female workers (SMR 1.70, 95% CI 1.04–2.63), especially in paper production, but not among male workers (SMR 0.91, 95% CI 0.79–1.04).

Eva Andersson, Bodil Persson, Ing-Liss Bryngelsson, Anders Magnuson, Håkan Westberg Cancer mortality in a Swedish cohort of pulp and paper mill workers International Archives of Occupational and Environmental Health
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Filed under: Occupational cancer,

Occupational exposures and sino-nasal cancer

Sino-nasal cancer has been consistently associated with exposure to wood dust, leather dust, nickel and chromium compounds; for other occupational hazards, the findings are somewhat mixed. The aim of this study was to investigate the risk of sino-nasal epithelial cancer (SNEC) by histological type with prior exposure to suspected occupational risk factors and, in particular, those in metalworking.

Some occupational risk factors were confirmed: wood dust, leather dust and organic solvents for adenocarcinoma and welding fumes and arsenic in squamous cell carcinoma. Treating cumulative exposure on a continuous scale, a significant effect of textile dusts was also observed for adenocarcinoma.

A case-control study on occupational risk factors for sino-nasal cancer
d’Errico, A, Pasian, S, Baratti, A, Zanelli, R, Alfonzo, S, Gilardi, L, Beatrice, F, Bena, A, Costa, G Occupational and Environmental Medicine 2009;66:448-455 Read the rest of this entry »

Filed under: Occupational cancer, Occupational exposure, , ,

Sunlight exposure and skin cancer

Recent research shows that it is very difficul to separate the effects of occupational and recreational solar UVR exposure (sunlight exposure); therefore the results of this review should be interpreted with caution. However, it is clear that solar UVR exposure does induce skin cancer. Protective measures should be taken in an attempt to reduce the burden of occupational skin cancer in Great Britain.

Solar ultraviolet radiation and skin cancer
Charlotte Young, Mathematical Sciences Unit, Health and Safety Laboratory, Harpur Hill, Buxton, Derbyshire SK17 9JN, UK Read the rest of this entry »

Filed under: Occupational cancer, , ,

Occupational cancer estimates from the UK

To estimate the current burden of cancer in Grat Britain, attributable fractions and numbers were estimated for mortality and incidence for sex type of cancer: bladder, lung, non-melanoma skin, and sinonasal cancers, leukaemia and mesothelioma.

It turned out that 4.9% of cancer deaths (men 8%; women 1.5%) were attributable to work-related carcinogens for these six cancers.

Asbestos contributed over half the occupational attributable deaths, followed by silica, diesel engine exhaust, radon, work as a painter, mineral oils in metal workers and in the printing industry, environmental tobacco smoke (non-smokers), work as a welder and dioxins.

You can read the full article from L Rushton et al in Occupational and Environmental Medicine 2008;65:789-800 free online:
The burden of cancer at work: estimation as the first step to prevention 

Read the rest of this entry »

Filed under: Occupational cancer,

Cotton dust exposure may reduce lung cancer risk

Several studies report a lower than expected mortality in lung cancer among workers exposed to organic dust. Here are two recent ones with the same remarkable outcome:

Lung and other cancer site mortality in a cohort of Italian cotton mill workers
G Mastrangelo, E Fadda, R Rylander, G Milan, U Fedeli, M Rossi di Schio, J H Lange
Occupational and Environmental Medicine 2008;65:697-700 (free abstract)

Evaluation of the mortality from lung and other cancer sites in a cohort of 3961 Italian cotton mill workers, divided into those working with carding (exposed to high levels of endotoxin-containing cotton dust) and other tasks, which generally have lower exposure. Standardised mortality ratios (SMRs), with 95% confidence intervals (CI), were calculated using death rates of the regional general population as a reference. Cancer mortality was analysed in relation to the length of employment in the two task groups.

Read the rest of this entry »

Filed under: Occupational cancer,

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